I know the public SDK currently doesn't allow for it, be wouldn't it br worthwhile for Roku boxes with USB ports to have Skype capability?
Throw in a USB webcam/mic combo and make calls from your TV. The Roku is on 24/7 anyway, so it would really be an ideal situation. My computer gets turned off when it's not in use.
Or maybe this would be better suited for the new Roku slated to be released this year? Either way -- I would love something like this.
4200R [Roku 3]
3100X [Roku 2 XS]
2050X [Roku XD]
42" VIZIO via HDMI @ 1080p