Ah, that old chestnut. I suggest you have a read of Donald Norman's Design of Everyday Things. In general, the more general purpose an item is the less usable it is for specific tasks.
Consider a good VCR remote with a jog and shuttle disk and ring, and different shaped buttons for each control. Now try that in a dark room versus a universal remote, or even worse a universal remote with a touch screen where you don't get tactile feedback to know if you hit the button or the right button. Try not just pause and play but tasks like fast forwarding through ads or to find a particular scene. Try it without looking at the remote. In these cases the specialized remote wins hands down. Of course this does not stop a lot of universal remotes being sold based on the power they give you but my experience has been that often they can make usability worse, not better. Hence my request to have one, already purpose built, remote for my stereo. Right now I use the Roku remote, but have to reach for the really ugly grid of buttons on my Rotel remote for volume. I think adding a programmable power button and making the existing volume buttons programmable would give a much better experience than a universal remote.
Its tactile, the whole thing lights up, motion sensor, buttons have nubs so you can even use it if your blind (unlike the Roku SB remote where I get the 4 way and select all messed up in the dark. Which it had a numb on the select key), set up is a cake walk, their tech support is second to none, one button launch. Has all the codes of the OE remote is you go to that menu, and if you have a Rotel, then the MSRP of $249 should be no issue.
I guess "880" is not a word...LOL