4/19/2011 - XD stopped responding to remote 10 minutes after I started watching Hulu.
Exact same thing happens to me with XD|S. I usually notice it if we put a HuluPlus video on pause, walk away for some time, then come back and try to play it. It becomes unresponsive to the remote. In actuality, it does seem to listen to it, but the response time is MINUTES. I end up resetting the Roku box to clear it.
This might be an issue with the HuluPlus channel programing as opposed to the box itself (?). I don't have the issue on other channels.